Article 12320

Title of the article

THE ASSESSMENT OF CYTOKINE PROFILE, C-REACTIVE PROTEIN AND GLUCOSE LEVEL IN PATIENTS
WITH ISCHEMIC STROKE IN THE ACUTE PERIOD OF DISEASE 

Authors

Levashova Ol'ga Anatol'evna, Candidate of biological sciences, associate professor, sub-department of human physiology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: olga.lewashowa@yandex.ru
Orlova Ekaterina Aleksandrovna, Doctor of medical sciences, professor, sub-department of allergology and immunology, Penza Institute of Advanced Medical Studies – branch of the Federal State Government-financed Educational Establishment of Additional Professional Education “Russian Medical Academy of Life-long Professional Learning” of the Ministry of Healthcare of the Russian Federation (8A Stasova street, Penza, Russia), E-mail: lisaorl@yandex.ru
Zolkornyaev Iskander Gusmanovich, Doctor of medical sciences, associate professor, sub-department of neurology, Penza Institute of Advanced Medical Studies – branch of the Federal State Government-financed Educational Establishment of Additional Professional Education “Russian Medical Academy of Life-long Professional Learning” of the Ministry of Healthcare of the Russian Federation (8A Stasova street, Penza, Russia), E-mail: isckan85@rambler.ru
Mikulyak Nadezhda Ivanovna, Doctor of medical sciences, associate professor, head of the sub-department of human physiology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: normphys@mail.ru
Moiseev Yakov Petrovich, Student, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: moiseeva_pharm@mail.ru 

Index UDK

616.831–005–092 

DOI

10.21685/2072-3032-2020-3-12 

Abstract

Background. The objective of this study is a comparative assessment of the levels of the main pro- and anti-inflammatory cytokines (IL-1, IL-6, IL-10) in blood serum, in spontaneous and stimulated production in vitro, as well as glucose and Creactive protein levels in patients with ischemic stroke in the acute disease stage.
Materials and methods. 98 patients with ischemic stroke has been included in the study, they was hospitalized on the first day of the disease progression. The inclusion criteria for the main examined patients group were: ischemic stroke, confirmed by neuroimaging methods (computed tomography - CT). The average patients’ age was 65 ± 7.8 years old. The National Institutes of Health (NIHSS) Stroke Scale was used to standardize neurological deficits. The exclusion criterion was a history of diabetes.
Results. The conducted study showed that multidirectional changes in various pro- and anti-inflammatory cytokines levels were observed. The most significant changes of these biologically active substances levels were observed during assessment in cell culture (with spontaneous and stimulated production). Severe cerebral ischemia is accompanied with an increase blood serum glucose level, which may be additional criterion in the assessment of prognosis of disease clinical course. The correlation between the carbohydrate metabolism violation and the C-reactive protein level is also established.
Conclusions. The total of received results allow us to talk about the effect of cytokines on glucose homeostasis, which is another evidence of the close regulatory interaction of the immune, nervous and endocrine systems in the body both in normal and in pathology. 

Key words

ischemic stroke, cytokines, hyperglycemia, C-reactive protein 

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Дата создания: 19.10.2020 13:03
Дата обновления: 20.10.2020 11:34